A Sensitive Whole Blood Assay Detects Antigen-Stimulated Cytokine Release From CD4+ T Cells and Facilitates Immunomonitoring in a Phase 2 Clinical Trial of Nexvax2 in Coeliac Disease.

Front Immunol · 2021 · PMC8171185 · PMID 34093551

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almost reached significanceno p-value reported

Statistical comparisons between the twelve Nexvax2 and nine placebo-treated patients in this sub-study almost reached significance for the reduction of IL-2 and IFN-γ release stimulated by gluten peptides in Nexvax2, and IL-2 release stimulated by the expanded pool of gluten peptides.

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