However, mechanical AVR was associated with a modestly significant less hazard of death (HR, 0.83; 95% CI, 0.74–0.94) compared with bioprosthetic AVR.
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Outcomes of Surgical Mitral and Aortic Valve Replacements Among Kidney Transplant Candidates: Implications for Valve Selection.
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Since patients with mAVR were significantly younger, had less cardiovascular disease burden, had lower prevalence of chronic obstructive pulmonary disease, higher rates of KT, and the fact that the effect estimate is marginally significant, we believe that the finding of statistically significant survival benefit associated with mAVR compared with bAVR is reflective of selection bias.