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The HD-Domain Metalloprotein Superfamily: An Apparent Common Protein Scaffold with Diverse Chemistries.

Catalysts · 2020 · PMC8177086 · PMID 34094591

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an observed trendno p-value reported
There is an observed trend, in which bulkier substrates or compounds with multiple hydrolyzable bonds are most likely to be processed by multinuclear HD-domain enzymes.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.