We next compared tumor formation between Alb-Cre + ; Atg7 fl/fl ; Pten +/fl or Alb-Cre + ; Atg5 fl/fl ; Pten +/fl and Alb-Cre + ; Atg7 fl/fl ; Pten +/fl ; Taz fl/fl or Alb-Cre + ; Atg5 fl/fl ; Pten +/fl ; Taz fl/fl in 140-day-old livers and noted that TAZ deletion caused a highly significant decrease in tumorigenesis in autophagy-deficient livers ( Fig. 6, C and D , and fig.
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Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver.
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