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The efficacy of the application of the curative criteria of the 5<sup>rd</sup> edition Japanese gastric cancer treatment guidelines for early adenocarcinoma of the esophagogastric junction treated by endoscopic submucosal dissection.

Saudi J Gastroenterol · 2021 · PMC8183359 · PMID 33642353

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an increasing trendno p-value reported
INTRODUCTION The incidence of adenocarcinoma of the esophagogastric junction (AEGJ) as a consequence of gastroesophageal reflux disease and Barrett's esophagus showed an increasing trend over the last decades in Western countries.[ 1 , 2 ] Although AEGJ accounted for only 1%-4% of the esophageal carcinoma in Eastern countries, including China and Japan, it is believed that the incidence of AEGJ will increase in Eastern countries in the future due to the decreasing incidence of Helicobacter pylori infection.[ 3 , 4 ] Esophagectomy has long been regarded as the gold standard treatment for early AEGJ.

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