Pore mutation N617D in the skeletal muscle DHPR blocks Ca²⁺ influx due to atypical high-affinity Ca²⁺ binding.

However, increase in extracellular Ca 2+ concentration to 1 μM showed a highly significant (p<0.001) reduction of Li + currents through nc DHPR (I max = −0.47 ± 0.10 pA/pF; n = 8) compared to wt (I max = −1.68 ± 0.25 pA/pF; n = 6) myotubes ( Figure 3b ).

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