Dopaminergic organization of striatum is linked to cortical activity and brain expression of genes associated with psychiatric illness.

Out-of-sample cross-validation and significance testing against 10,000 between subject permutations of the imaging data demonstrated a highly significant mode of covariation between the pattern of D2/3 receptor availability in the striatum and the pattern of CBF (mean out of sample r p = 0.51, P < 0.001) ( Fig. 3, A and B ).

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