Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study.

After the removal of DNMT1, the association of MAST with the subject groups regained a borderline significance ( p value = 0.045 in model 21).

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2 . All CpG sites showed a weak positive, albeit highly significant, linear correlation with age, both in non-parametric (Spearman) and parametric (Pearson) tests, which included a bootstrap stratified resampling in order to control for the effects of sex and recruitment centre (Supplementary Table S2 and Fig. 3 ).

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