Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.

Mol Psychiatry · 2021 · PMC8190957 · PMID 32647257

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highly significantno p-value reported

We observed that T21 organoids produce statistically highly significant increases in all four of these ratios, relative to isogenic D21, or non-isogenic Dup APP organoids ( Fig. 1b ).

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