Serum calprotectin (S100A8/A9): a promising biomarker in diagnosis and follow-up in different subgroups of juvenile idiopathic arthritis.

16 The second key point of this study underscores the utility of sCal as a highly significant predictive marker of relapse when measured in patients in remission, as outlined by other teams. 17–20 30 35 The very high sCal values found in patients with a subsequent flare may be striking, but they were not skewed by possible systemic forms; indeed, these patients had persistent-oligoarthritis or seronegative polyarthritis forms of JIA. sCal could therefore be a marker of residual disease activity, even in the absence of clinical or biological signs of persistent inflammation.

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