Non-hotspot PIK3CA mutations are more frequent in CLOVES than in common or combined lymphatic malformations.

There was a statistically highly significant difference in VAF between common and combined LMs versus syndromes (PROS) ( p value = 1.425 × 10 –4 , Fig. 4 a) and versus CLOVES ( p value = 6.510 × 10 –5 , Fig. 4 b), as well as between common LMs versus syndromes (PROS) ( p value = 6.765 × 10 –5 , Fig. 4 c) and versus CLOVES ( p value = 5.290 × 10 –4 , Fig. 4 d).

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