Barely Significant
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Association of the 2016 US Centers for Disease Control and Prevention Opioid Prescribing Guideline With Changes in Opioid Dispensing After Surgery.

JAMA Netw Open · 2021 · PMC8196343 · PMID 34115128

Europe PMCDOI
1
hedged sentence
0.0010
closest p · 0.0× alpha
0.0010
boldest claim

The sentences

an increasing trendP = .001actually significant
The total amount of opioids dispensed in the first prescription after surgery decreased in the 2 years following the CDC guideline release, compared with an increasing trend in the 2 years prior (prerelease trend: 1.43 MME/month; 95% CI, 0.62 to 2.24 MME/month; P = .001; postrelease trend: −2.18 MME/month; 95% CI, −3.01 to −1.35 MME/month; P < .001; trend change: −3.61 MME/month; 95% CI, −4.87 to −2.35 MME/month; P < .001).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.