As displayed in Figure 1 D, cholesterol treatment leads to an increasing trend in the indicated glycolytic intermediate levels and significantly enhances the accumulation of glyceraldehyde 3-phosphate (GA3P), fructose-1,6-bisphosphate (F1-.6 bis P), and 2-phosphoglycerate/3-phosphoglycerate (2PG/3PG) metabolite levels.
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Cholesterol-Induced Metabolic Reprogramming in Breast Cancer Cells Is Mediated via the ERRα Pathway.
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