highly significantp < 0.0001
Two-way ANOVA Sidak’s multiple comparisons test was used to compare the mean of three values obtained from three independent conditions, using GraphPad Prism version 7 (GraphPad Software, La Jolla, California, U.S.); * p < 0.05 indicates a significant result; ** p < 0.01 a very significant result, *** p < 0.001 a highly significant result; and **** p < 0.0001 an extremely significant result. 3.