Diffusion models reveal white matter microstructural changes with ageing, pathology and cognition.

This is consistent with a previous DTI study in cerebrovascular disease that reported highly significant correlations of genu and splenium with global cognitive performance. 40 Impaired interhemispheric connection pathways contribute to multiple impaired cognitive functions, such as impaired memory, psychomotor speed, frontal lobe mediated attention and executive function. 88 , 89 Additionally, these observations replicated our recent study in MCI that showed greater predictability of high FA of genu on better cognitive performance, 75 even after controlling for amyloid and tau PET.

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