CRISPR mediated targeting of DUX4 distal regulatory element represses DUX4 target genes dysregulated in Facioscapulohumeral muscular dystrophy.

Sci Rep · 2021 · PMC8206090 · PMID 34131248

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highly significantno p-value reported

We found and highly significant downregulation of TRIM43 and ZSCAN4 with the CR-2A/CR-11 pair, whereas despite a substantial reduction, change in MBD3L2 levels did not reach significance.

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