Correlated and geographically predictable Neanderthal and Denisovan legacies are difficult to reconcile with a simple model based on inter-breeding.

Using the same data, I also fitted a multiple regression and found that nd NEA is predicted by nd DEN ( p < 2.2 × 10 −16 ) but that distance from Africa ( p = 1.4 × 10 −8 ) and the interaction term between these two predictors ( p = 0.0002) are also highly significant. 2.3 .

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