Cas9-targeted nanopore sequencing reveals epigenetic heterogeneity after <i>de novo</i> assembly of native full-length hepatitis B virus genomes.

Spearman’s correlation of the methylation levels obtained for the fully methylated and unmethylated HBV controls with Nanopolish and Guppy+Medaka indicated a highly significant correlation ( R =0.83, P <2.2 −16 ) ( Fig. 2e ).

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