Serum Complement C3 and C4 and COVID-19 Severity and Mortality: A Systematic Review and Meta-Analysis With Meta-Regression.

Front Immunol · 2021 · PMC8215447 · PMID 34163491

Europe PMC DOI

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Furthermore, after removing the studies conducted at the Renmin Hospital, Wuhan, barring the largest ones for disease severity ( 28 ) and survival status ( 39 ), the SMD remained substantially unchanged, albeit borderline significant (SMD -0.28, 95% CI -0.56 to 0.00, p=0.05; I 2 = 88.2%, p<0.001) ( Figure 4B ).

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