Barely Significant
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Failed, Interrupted, or Inconclusive Trials on Neuroprotective and Neuroregenerative Treatment Strategies in Multiple Sclerosis: Update 2015-2020.

Drugs · 2021 · PMC8217012 · PMID 34086251

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a slight trendno p-value reported
Also, a slight trend of stronger disease progression related to MRI criteria was observed in the 4 mg/day group compared to patients treated with 0.3 mg/day diazoxide.

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a positive trendno p-value reported
Comment While a first exploratory pilot study indicated improvements under EPO treatment, especially in terms of motor functions [ 244 ], these results could not be reproduced in the reviewed Phase II trial, even though a positive trend was observed [ 246 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.