A549 in-silico 1.0: A first computational model to simulate cell cycle dependent ion current modulation in the human lung adenocarcinoma.

However, with regard to the calcium modeling it is important to note that the estimation of the local calcium concentration in this first model version is based on a simplified approach, assuming a certain steady state concentration which does not account for the complex local calcium dynamics.[ 61 ] Nevertheless, the local calcium distribution and time evolution in microdomains of the cell is highly significant for the activity of responding ion channels and, subsequently, affect the entire electric properties of the cell membrane.[ 89 – 92 ] Thus, to overcome this limitation and to further increase the model accuracy, a spatio-temporal modeling approach, addressing the heterogenous calcium profile and dynamics in the ER-PM junction provoked by local calcium release of CRAC channels from the edoplasmatic reticulum needs to be considered in future work of a more advanced model version.

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