Similar to previous reports, 19 , 23 in pre-epileptic conditions, we found that all individual mice expressing ChR2-mCherry in MSGNs had a highly significant increase in the entrainment power ratio upon optical stimulation when compared to baseline epochs at the intermediate ipsilateral channel (Kolmogorov-Smirnov test, n = 120 stimulation epochs per mouse, n = 5 mice, P = 9.19 × 10 −14 , 3.5 × 10 −25 , 2.95 × 10 −11 , 3.61 × 10 −21 and 3.41 × 10 −43 ) ( Fig. 3B ).
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Medial septal GABAergic neurons reduce seizure duration upon optogenetic closed-loop stimulation.
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