Clozapine re-challenge and initiation following neutropenia: a review and case series of 14 patients in a high-secure forensic hospital.

98 Given that controlled trials are highly unlikely, teams embarking on rechallenge should attempt to enrol their patients into the worldwide efforts to understand the aetiologias of CIN and CIA and report their results, ideally including the variables which may be significant; the exact details of the initial neutropenia, concomitant drug use, patient demographics and clinical details including ethnicity and Duffy type as well as the rechallenge titration schedule.

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