During the fetal and neonatal periods, the central nervous system (CNS) displays highly significant plasticity and is vulnerable to changes by prenatal influences such as prenatal opioid exposure [ 6 – 8 ].
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Enhanced H3K4 Trimethylation in TNF-<i>α</i> Promoter Gene Locus with Cell Apoptosis in the Ventral-Medial Striatum following Opioid Withdrawal of Neonatal Rat Offspring from Morphine-Addicted Mothers.
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