Focused CRISPR-Cas9 genetic screening reveals USO1 as a vulnerability in B-cell acute lymphoblastic leukemia.

We found a highly significant overlap between genes that were positively correlated with USO1 across the B-ALL samples and downregulated in USO1-depleted cells (Hypergeometric test; p < 0.0001), but not in genes that were upregulated in USO1-depleted cells (non-significant p value) (Fig. 4 F, Supplementary 5C & 5D).

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