TKI-Resistant Renal Cancer Secretes Low-Level Exosomal miR-549a to Induce Vascular Permeability and Angiogenesis to Promote Tumor Metastasis.

Under fluorescence microscopy, an increasing trend of 786-O early apoptotic cells (annexin-V single positive), late apoptotic cells (annexin-V and PI double positive) as well as necrotic cells (PI single positive) could be observed with increasing sorafenib concentration, while the change of 786-O-SR counterpart was less obvious ( Figure 1D ).

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