Barely Significant
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Major Depression: One Brain, One Disease, One Set of Intertwined Processes.

Cells · 2021 · PMC8224372 · PMID 34064233

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might be significantno p-value reported
Low nicotine levels administered chronically (for example, by the nicotine patch) may desensitize nAChRs [ 304 , 305 ]; therefore, nAChRs blockade might be significant in the manifestation of the influence of nicotinic substances on depressive symptoms.

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