Hepatic <i>Nfe2l2</i> Is Not an Essential Mediator of the Metabolic Phenotype Produced by Dietary Methionine Restriction.

Using a pairwise comparison of 5286 genes with adjP ≤ 0.1 for log fold change of WT MR versus WT Con and NRF2 KO MR versus NRF2 KO Con, the correlation of the effect of MR in the two genotypes was highly significant (R 2 = 0.64, p < 2.2 × 10 −16 , Supplementary Figure S2 ).

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