Voriconazole Use in Children: Therapeutic Drug Monitoring and Control of Inflammation as Key Points for Optimal Treatment.

J Fungi (Basel) · 2021 · PMC8227726 · PMID 34200506

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0700

boldest claim

The sentences

a statistical trendp = 0.054so close (0.05 < p ≤ 0.1)

There were, however, associations between hypoalbuminemia and increased TBIL (MLM, F = 4.96, p = 0.03), oral administration and increased ALT (MLM, F = 4.09, p = 0.04), and a statistical trend to ALT elevation when dual antifungal therapy was used (MLM, F = 3.75, p = 0.054). 4.

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marginally significantp = 0.07so close (0.05 < p ≤ 0.1)

Multivariate analysis showed no significant associations of any of the variables studied with plasma voriconazole variability or treatment effectiveness, except a marginally significant relationship between normal or only slightly elevated CRP and adequate plasma drug concentrations (MLM, F = 3.22, p = 0.07).

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