extremely significantp -value < 0.0001
For example, in the case of LEC-PVA nanoparticles at a 15 μM concentration, the cytotoxic effect was extremely significant (compared to that of the free MTX) from 48 h on inside the 100-μm high channels ( p -value < 0.0001), while it was already significant after 36 h of treatment inside the 50-μm high channels ( p -value < 0.03).