Impact of Transcranial Direct Current Stimulation on Cognitive Function, Brain Functional Segregation, and Integration in Patients with Mild Cognitive Impairment According to Amyloid-Beta Deposition and <i>APOE</i> ε4-Allele: A Pilot Study.

Although as well as a nonsignificant interaction between tDCS and AD risk factors, there was a statistical trend toward an interaction between tDCS and the APOE ε4-allele, possibly attributable to increased aMPFC DC after tDCS application in MCI patients with Aβ deposits, yielding a large effect size ( p = 0.056, partial η 2 = 0.138, Figure 1 A).

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In terms of functional segregation parameters after anodal-tDCS application, our MCI patients with APOE ε4-allele displayed increased local intrinsic brain activity in DMN hub regions and AD compensatory regions, in which previous studies have shown a decreasing trend of fALFF across the AD spectrum [ 45 ].

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