Right Ventricle Remodeling Metabolic Signature in Experimental Pulmonary Hypertension Models of Chronic Hypoxia and Monocrotaline Exposure.

Orotate was the most impacted metabolite from the pyrimidine metabolic pathway, with fold changes >2 in RV of both MCT and CH models and with highly significant p -values in CH-PH heart and plasma ( p < 0.0001) ( Table 2 and Figure 3 (A4,B4,C4)).

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