Multiplatform metabolomics for an integrative exploration of metabolic syndrome in older men.

Differences of most of the MetS criteria quantitative variables were highly significant between cases and controls (BH corrected p-values from 10 −5 to 10 −21 , Table 1 ; Supplementary Fig. 1).

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In addition, despite the fact that total dietary fiber intake was at the limit of significance, the evaluation of the consumption of cereal products, based on the Canadian Food Guide recommended intakes for grain products (Canadian-Healthy Eating Index, C-HEI) was significantly lower in cases in comparison to controls (corrected p-value = 0.052 and 0.013, respectively). 4.2 Serum metabolomes in the NuAge sub-cohort Given the high diversity of metabolites present over a wide concentration range in biological samples, proper MetS evaluation requires a broad metabolome coverage.

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