A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion.

Indeed, we observed a moderate, though highly significant correlation between CDS length and fold change (FC) in translation (r 2 = 0.26; p < 2.2 × 10 −16 ), which produces a downregulatory effect for genes with long CDSs and, vice versa, an upregulatory effect for genes with short CDSs (Fig. 2 C).

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