Depletion of LAG-3⁺ T Cells Translated to Pharmacology and Improvement in Psoriasis Disease Activity: A Phase I Randomized Study of mAb GSK2831781.

Epigenetic quantification 37 of skin leukocytes by qRT‐PCR showed that, consistent with immunohistochemistry data ( Figure 4 ), there was a dose‐dependent trend toward a reduction in CD3 + T cells and a weak trend toward a reduction in LAG‐3 + cells at 5 mg/kg ( Figure 4b ).

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