Quinomycin A reduces cyst progression in polycystic kidney disease.

Quantification of cilia length within kidneys confirmed that there was a highly significant ( P < .0001) cilia length reduction following Quinomycin A treatment in PKD mice, indicating that Quinomycin A restores cilia lengths in a PKD mouse model (Figure 6B ). 4 DISCUSSION In this study, we show that Quinomycin A effectively reduces in vitro cyst growth of primary cyst epithelial cells obtained from ADPKD patients.

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Western blots revealed that there was a decreasing trend in Notch3 IC protein following Quinomycin A treatment in PKD mice, it did not reach significance (Figure 5B ).

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