The central phenyl ring is seen to be highly significant in the binding interactions to bring about PPARγ agonism though substitution with a benzdihydropyran and naphthyl groups (englitazone ( 64 ) and netoglitazone ( 65 ) respectively) are also well tolerated.
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Thiazolidinediones: An In-Depth Study of Their Synthesis and Application to Medicinal Chemistry in the Treatment of Diabetes Mellitus.
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