Multi-trajectories of lipid indices with incident cardiovascular disease, heart failure, and all-cause mortality: 23 years follow-up of two US cohort studies.

Interestingly, we found a decreasing trend in LDL-C over time, although only 40 percent of participants were on lipid-lowering agents.

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Nevertheless, the multi-trajectory group with the highest HDL-C level increased the risk of death by 20 percent with a marginal significance.

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We also observed that individuals presenting with very high HDL-C levels throughout the adult life course were at a significantly increased risk of incident CVD and heart failure, and a marginally significant risk of death than those with optimal lipid profile, after adjusting for confounders.

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