FOXP1 negatively regulates intrinsic excitability in D2 striatal projection neurons by promoting inwardly rectifying and leak potassium currents.

There was a statistical trend for a depolarized resting potential ( p = 0.06, Fig. 1N ) and input resistance was higher (Fig. 1O ) in Foxp1 vcKO D2 SPNs, which was consistent with the down-regulation of a subthreshold K + current.

also in 2,798 other papers