almost significantp=0.0516
Treatment was stopped because of AEs in 26 (13%) patients ( Table S2 ). Management of irAEs and Impact of Our Standardised Management-Based Protocol Univariate analysis revealed an almost significant worse OS (p=0.0516) for patients who underwent an initial evaluation with an IMS before ICI initiation, but this was not confirmed by multivariate analysis ( Table S1 ).