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Stereoselective ketamine effect on cardiac output: a population pharmacokinetic/pharmacodynamic modelling study in healthy volunteers.

Br J Anaesth · 2021 · PMC8258972 · PMID 33896589

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a positive trendno p-value reported
Sigtermans and colleagues 14 observed a positive trend term in their study on the effect of ketamine on anti-nociception.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.