Plasma biomarker profiles and the correlation with cognitive function across the clinical spectrum of Alzheimer's disease.

1 , plasma Aβ 1-40 , Aβ 1-42 , and Aβ 1-42 /Aβ 1-40 ratio showed a descending trend, while plasma t-tau, NfL, and p-tau181 exhibited an increasing trend across groups with the increasing CDR scores in general.

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Discussion The present study demonstrated that plasma Aβ 1-40 , Aβ 1-42 , and Aβ 1-42 /Aβ 1-40 had a decreasing trend, while plasma t-tau, NfL, and p-tau181 escalated along the different stages of cognitive impairment as the CDR score increased from 0 to 3.

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