highly significantp value = 0.00265
This reduction in HIV-1 particle release is highly significant ( n = 3 independent experiments, p value = 0.00265, Student’s t -test, and ANOVA statistical test for multiple comparisons indicate p value = 0.0089) since the gene editing of IRSp53 cannot be complete, nor edited by CRISPR/Cas9 knockout, without being toxic for the cells.