CaMKIV Signaling Is Not Essential for the Maintenance of Intrinsic or Synaptic Properties in Mouse Visual Cortex.

The duration of CaMKIV manipulation may be significant, as in vitro experiments have generally used either short pharmacological manipulations or brief genetic manipulations lasting only 24 h or so ( Pratt et al., 2011 ; Joseph and Turrigiano, 2017 ) while our approach (conditional knock-down or viral expression in vivo ) limited us to examining the impact of longer manipulations.

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