NAD⁺ homeostasis in human health and disease.

Interestingly, these in silico predictions were validated through the detection of lower concentrations of NAD + in red blood cells (Koenekoop et al, 2012 ) and fibroblasts (Falk et al, 2012 ) of affected individuals compared to controls, although in the latter case this difference was only borderline significant ( P = 0.067).

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