highly significantP = 0.014
By quantifying the extent to which members of the same clonal family were found in both EM skin and blood, we found the overlap was highly significant for both B cells (paired t test, P = 0.014; Supplemental Figure 13A ) and T cells ( P = 6.1 × 10 –5 ; Supplemental Figure 13B ), suggesting a meaningful clonal connection between the 2 sites.