What Lies Ahead for Young Hearts in the 21<sup>st</sup> Century - Is It Double Trouble of Acute Rheumatic Fever and Kawasaki Disease in Developing Countries?

Front Cardiovasc Med · 2021 · PMC8263915 · PMID 34250047

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a decreasing trendno p-value reported

Although population-based data reflecting the trend of ARF incidence in China are sparse, hospital-based data have noted a decreasing trend similar to other regions of the world ( 39 , 41 ).

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an increasing trendno p-value reported

Similarly, many regions across the globe classified as “high-risk” for ARF have witnessed an increasing trend in the incidence of KD.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.