Targeting JAK-STAT Signalling Alters PsA Synovial Fibroblast Pro-Inflammatory and Metabolic Function.

Front Immunol · 2021 · PMC8264423 · PMID 34248953

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an increasing trendno p-value reported

In this study, we show that JAKi significantly reduce the secretion of OSM-induced pro-inflammatory mediators MCP-1 and IL-6, while displaying an increasing trend in IL-8 secretion, this differential regulation is consistent with the pleiotropic effects of OSM ( 36 ).

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