Barely Significant
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Oropharyngeal Probiotic ENT-K12 Prevents Respiratory Tract Infections Among Frontline Medical Staff Fighting Against COVID-19: A Pilot Study.

Front Bioeng Biotechnol · 2021 · PMC8264449 · PMID 34249878

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highly significantno p-value reported
Recent studies have shown that the microbiota in the lung contributes to immunological homeostasis and can potentially, when affected by dysbiosis, alter susceptibility to viral infection, and with respect to COVID-19, a highly significant difference in the lung microbiota composition has been observed between patients with COVID-19 pneumonia and healthy subjects, implying a dysbiosis occurred in the lung microbiota of patients who had a pathogen-enriched microbiota; not only can lung microbiota dysbiosis create a more fertile ground for viral aggression, but it can also promote a worsening of the patient condition ( Zijie et al., 2020 ).

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