close to significancep = 0.065
Interestingly, the interaction between metal and NP was close to significance for the transcription of bcl2 ( p = 0.065), nrf2 ( p = 0.084) and gsta ( p = 0.078), but only the three factors (NP, metal and dosage) produced a significant interaction in the transcription of nrf2 , the master transcription factor of antioxidant enzymes.